Immunohistochemical characterization of hepatic lesions associated with migrating larvae of Ascaris suum in pigs

Citation
J. Perez et al., Immunohistochemical characterization of hepatic lesions associated with migrating larvae of Ascaris suum in pigs, J COMP PATH, 124(2-3), 2001, pp. 200-206
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF COMPARATIVE PATHOLOGY
ISSN journal
0021-9975 → ACNP
Volume
124
Issue
2-3
Year of publication
2001
Pages
200 - 206
Database
ISI
SICI code
0021-9975(200102/04)124:2-3<200:ICOHLA>2.0.ZU;2-D
Abstract
This paper describes the histopathological features and the cellular distri bution of T lymphocytes (CD3), B cells (CD79a), immunoglobulin (IgG, IgA, I gM)-bearing plasma cells, macrophages (Mac387 and alpha-1-antitrypsin), MHC class II antigen and S-100 protein in hepatic white spots associated with naturally occurring Ascaris suum parasitism in 35 pigs. Hepatic granulomas were observed in 10 pigs, whereas lymphoid proliferation with a diffuse or lymphonodular pattern was the main histopathological lesion in immunoreacti ve cells with all antibodies tested was closely similar to that found in th e cortex of lymph nodes. Thus, lymphoid follicles were composed mainly of C D79a(+) B cells and interfollicular tissue was composed mainly of CD3(+) T lymphocytes. The presence of follicular dendritic and interdigitating cells expressing S-100 protein and MHC class II antigen in lymphonodular lesions suggested that these are highly organized structures developed to enhance antigen presentation to B and T cells, and consequently the local immune re sponse against the parasite. The humoral local response was represented mai nly by IgG-secreting plasma cells. (C) 2001 Harcourt Publishers Ltd.