ONDANSETRON PREVENTS POSTOPERATIVE NAUSEA AND VOMITING IN WOMEN OUTPATIENTS

Citation
Sn. Khalil et al., ONDANSETRON PREVENTS POSTOPERATIVE NAUSEA AND VOMITING IN WOMEN OUTPATIENTS, Anesthesia and analgesia, 79(5), 1994, pp. 845-851
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
Journal title
ISSN journal
0003-2999
Volume
79
Issue
5
Year of publication
1994
Pages
845 - 851
Database
ISI
SICI code
0003-2999(1994)79:5<845:OPPNAV>2.0.ZU;2-7
Abstract
Three doses of intravenous (IV) ondansetron, 1 mg, 4 mg, and 8 mg, wer e compared to placebo for their antiemetic effect and safety. The drug s or placebo were administered in a double-blind manner, prophylactica lly to 589 women undergoing elective outpatient surgical procedures un der nitrous oxide opioid-based general endotracheal anesthesia. In the postanesthesia care unit, the number of emetic episodes, periodic ass essments of nausea severity using an 11-point scale (0 = no nausea; 10 = worst nausea), vital signs, and adverse events were collected by an independent observer for 2 h. Upon discharge, identical information, with the exception of vital signs, was collected from the patients' di ary and via phone call. One pre- and two poststudy blood specimens for hematology and chemistries were evaluated. During the initial 2 h, pa tients receiving any dose of ondansetron had significantly better comp lete response rates (no emesis) than those receiving placebo. Over the 24-h study period, patients who received either 4 mg or 8 mg ondanset ron continued to have significantly greater complete response rates. A dverse events were minor, and ondansetron-treated patients had profile s similar to those of the placebo. Heart rate, blood pressure, respira tory rate, and laboratory safety variables were not different among th e groups. Ondansetron did not prolong awakening time. This study indic ates that ondansetron is a safe and effective prophylactic antiemetic for women who have outpatient surgery under nitrous oxide opioid-based general anesthesia.