Potential association of pseudoexfoliation syndrome (PEX) with age-relatedmacular degeneration (ARMD): review of the literature

Authors
Citation
F. Kling et J. Colin, Potential association of pseudoexfoliation syndrome (PEX) with age-relatedmacular degeneration (ARMD): review of the literature, J FR OPHTAL, 24(1), 2001, pp. 7-12
Citations number
47
Language
FRANCESE
art.tipo
Review
Categorie Soggetti
Optalmology
Journal title
JOURNAL FRANCAIS D OPHTALMOLOGIE
ISSN journal
0181-5512 → ACNP
Volume
24
Issue
1
Year of publication
2001
Pages
7 - 12
Database
ISI
SICI code
0181-5512(200101)24:1<7:PAOPS(>2.0.ZU;2-6
Abstract
Purpose: Authors report an unexpected association between PEX and ARMD. It was an additional result of a study, that analysed possible systemic sympto ms of pseudoexfoliation material in visceral organs. They reviewed literatu re data for both, concerning epidemiology and physiopathogeny. Material and methods: We conducted an age-and sex matched study of 142 pati ents in Brittany, 71 PEX and 71 controls, 31 men and 40 women in the 2 grou ps. The statistical study was performed with Epi Info 6.0 software using th e X2 of Mantel-Haenszel Test. Results: Statistical positive relation was found between PEX and ARMD (p=0. 02), both increasing with age. Discussion and conclusion: Part of epidemiology seems to be similar in PEX and ARMD, especially environment role (particularly solar radiations), indi vidual factors, and genetic predisposition. For the first time, in may 1999 , a genetic localization of PEX was discovered on the chromosome II, and ne arly of one loci of ARMD multiple localizations.