F. Kling et J. Colin, Potential association of pseudoexfoliation syndrome (PEX) with age-relatedmacular degeneration (ARMD): review of the literature, J FR OPHTAL, 24(1), 2001, pp. 7-12
Purpose: Authors report an unexpected association between PEX and ARMD. It
was an additional result of a study, that analysed possible systemic sympto
ms of pseudoexfoliation material in visceral organs. They reviewed literatu
re data for both, concerning epidemiology and physiopathogeny.
Material and methods: We conducted an age-and sex matched study of 142 pati
ents in Brittany, 71 PEX and 71 controls, 31 men and 40 women in the 2 grou
ps. The statistical study was performed with Epi Info 6.0 software using th
e X2 of Mantel-Haenszel Test.
Results: Statistical positive relation was found between PEX and ARMD (p=0.
02), both increasing with age.
Discussion and conclusion: Part of epidemiology seems to be similar in PEX
and ARMD, especially environment role (particularly solar radiations), indi
vidual factors, and genetic predisposition. For the first time, in may 1999
, a genetic localization of PEX was discovered on the chromosome II, and ne
arly of one loci of ARMD multiple localizations.