Hemodynamic effects of synephrine treatment in portal hypertensive rats

Citation
Yt. Huang et al., Hemodynamic effects of synephrine treatment in portal hypertensive rats, JPN J PHARM, 85(2), 2001, pp. 183-188
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
0021-5198 → ACNP
Volume
85
Issue
2
Year of publication
2001
Pages
183 - 188
Database
ISI
SICI code
0021-5198(200102)85:2<183:HEOSTI>2.0.ZU;2-M
Abstract
Synephrine, a sympathomimetic alpha (1)-adrenoceptor agonist, has been show n to induce dose-dependent portal hypotensive effects after acute intraveno us infusion. The present study was undertaken to investigate the hemodynami c effects of 8-day administration of synephrine in portal hypertensive rats . Portal hypertension was induced by either partial portal vein ligation (P VL) or bile duct ligation (BDL). Portal hypertensive rats were allocated in to one of two groups: vehicle group (0.1 N HCl, 0.5 ml/12 h) or synephrine group (1 mg/kg per 12 h), with 7 rats in each group. Synephrine or vehicle was administered by gavage into PVL and BDL rats for 8 consecutive days. Sy stemic as well as splanchnic hemodynamic parameters were measured thereafte r. Synephrine significantly ameliorated the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats (-13.5% and -1 0.1%, respectively), portal tributary blood flow (-19.5% and -20.4%) and ca rdiac index (-12.1% and -18.8%) were significantly reduced, while mean arte rial pressure (10.4% and 23.4%) and systemic (26.3% and 51.0%) as well as p ortal territory (47.1% and 67.7%) vascular resistance were enhanced by trea tment of synephrine as compared with vehicle treatment. Our results showed that eight-day administration of synephrine exerted beneficial hemodynamic effects in two models of portal hypertensive rats.