Development of squamous cell carcinoma from pre-existent oral leukoplakia:with respect to treatment modality

Citation
T. Saito et al., Development of squamous cell carcinoma from pre-existent oral leukoplakia:with respect to treatment modality, INT J OR M, 30(1), 2001, pp. 49-53
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
ISSN journal
0901-5027 → ACNP
Volume
30
Issue
1
Year of publication
2001
Pages
49 - 53
Database
ISI
SICI code
0901-5027(200102)30:1<49:DOSCCF>2.0.ZU;2-5
Abstract
The present study was undertaken in order to determine whether surgical tre atment of oral leukoplakia reduces the risk of the subsequent development o f carcinoma. This study included 142 patients with oral leukoplakia who rec eived or did not receive surgical treatment. All subjects were followed-up for more than 6 months with a mean follow-up period of 4 years. Malignant t ransformation rate was lower among patients who received surgical excision (1/75) than among those who did not receive surgical treatments (4/51). How ever, the malignant transformation rates were high in patients who received cryosurgery (3/12) or cryosurgery plus surgical excision (1/4). There was no obvious relation between the grade of epithelial dysplasia and the rate of malignant transformation. Our results suggest that surgical excision of oral leukoplakia may reduce the risk of the subsequent development of carci noma.