Objective: To find out whether preoperative serum concentrations of hepatoc
yte growth factor (HGF) can indicate the general condition of sick children
and can predict their postoperative inflammatory response.
Design: Non-randomised study.
Setting: University hospital, Japan. Subjects: 41 children who required ope
ration and 41 healthy controls.
Interventions: Samples of peripheral venous blood were obtained during the
Main outcome measures: Circulating concentrations of HGF, interleukin-6 (IL
-6), and C-reactive protein (CRP); neutrophil counts; and nutritional varia
bles including serum cholinesterase, albumin, and body weight: ideal body w
Results: The mean serum concentration of HGF in the patients was significan
tly higher than in the normal controls. Preoperative HGF was related to the
preoperative nutritional state, the postoperative IL-6 response, and the d
evelopment of infective complications.
Conclusions: The serum HGF concentration may be a useful variable for evalu
ating general condition and predicting perioperative surgical stress in sic