Sugar-modified nucleosides in past 10 years, a review

Citation
E. Ichikawa et K. Kato, Sugar-modified nucleosides in past 10 years, a review, CURR MED CH, 8(4), 2001, pp. 385-423
Citations number
185
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CURRENT MEDICINAL CHEMISTRY
ISSN journal
0929-8673 → ACNP
Volume
8
Issue
4
Year of publication
2001
Pages
385 - 423
Database
ISI
SICI code
0929-8673(200103)8:4<385:SNIP1Y>2.0.ZU;2-O
Abstract
In the search for effective, selective, and nontoxic antiviral acid antitum our agents, a variety of strategies have been devised to design nucleoside analogs. These strategies have involved several formal modifications of the naturally occurring nucleosides, especially, alteration of the carbohydrat e moiety. Since the naturally occurring purine nucleoside analog oxetanocin A and its derivatives have been found to be effective as anti-HIV-1 and an ti-herpes virus agents in 1986, the syntheses of different types of sugar-m odified nucleoside analogs have been reported. In this review we will give an overview of the sugar-modified nucleosides synthesized since the late 19 90 according to their structural types along with the synthetic routes of s ome selected nucleosides.