New mutation in ParE in a pneumococcal in vitro mutant resistant to fluoroquinolones

Citation
C. Janoir et al., New mutation in ParE in a pneumococcal in vitro mutant resistant to fluoroquinolones, ANTIM AG CH, 45(3), 2001, pp. 952-955
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
0066-4804 → ACNP
Volume
45
Issue
3
Year of publication
2001
Pages
952 - 955
Database
ISI
SICI code
0066-4804(200103)45:3<952:NMIPIA>2.0.ZU;2-N
Abstract
For an in vitro mutant of Streptococcus pneumoniae selected on moxifloxacin four- to eightfold-increased MICs of new fluoroquinolones, only a twofold- increased MIC of ciprofloxacin, and a twofold-decreased MIC of novobiocin w ere observed. This phenotype was conferred by two mutations: Ser81Phe in Gy rA and a novel undescribed His103Tyr mutation in ParE, outside the quinolon e resistance-determining region, in the putative ATP-binding site of topois omerase IV.