Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics

Citation
M. Yamamoto et al., Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics, ALC ALCOHOL, 36(1), 2001, pp. 70-74
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ALCOHOL AND ALCOHOLISM
ISSN journal
0735-0414 → ACNP
Volume
36
Issue
1
Year of publication
2001
Pages
70 - 74
Database
ISI
SICI code
0735-0414(200101/02)36:1<70:IOCREB>2.0.ZU;2-P
Abstract
We examined amounts of cAMP response element binding protein (CREB) and its phosphorylated form in post-mortem frontal and temporal cortices and cereb ella from alcoholics and controls by immunoblotting. No significant differe nces were observed in the levels of these proteins in each brain region, su ggesting that the assumed neuroadaptations to chronic ethanol intake may no t be reflected by quantitative alterations of CREB in alcoholic brain.