Plasma thrombomodulin levels in children with atopic dermatitis

Citation
S. Yoshijima et al., Plasma thrombomodulin levels in children with atopic dermatitis, ACT PAEDIAT, 90(2), 2001, pp. 130-132
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
ACTA PAEDIATRICA
ISSN journal
0803-5253 → ACNP
Volume
90
Issue
2
Year of publication
2001
Pages
130 - 132
Database
ISI
SICI code
0803-5253(200102)90:2<130:PTLICW>2.0.ZU;2-M
Abstract
Plasma thrombomodulin (TM) levels were measured in 68 patients with atopic dermatitis (AD) and 35 controls. Plasma TM levels in patients with AD were significantly higher than those of controls (p < 0.01). A significant corre lation was observed between plasma TM levels and skin scores of AD or perip heral eosinophil counts (p < 0.01). There was also a positive correlation b etween plasma TM and vascular cell adhesion molecule-1 levels (p < 0.05). Conclusion: These results suggest that plasma TM levels may reflect a sever ity of AD and/or endothelial cell activation induced by an allergic inflamm ation.