Plasma thrombomodulin (TM) levels were measured in 68 patients with atopic
dermatitis (AD) and 35 controls. Plasma TM levels in patients with AD were
significantly higher than those of controls (p < 0.01). A significant corre
lation was observed between plasma TM levels and skin scores of AD or perip
heral eosinophil counts (p < 0.01). There was also a positive correlation b
etween plasma TM and vascular cell adhesion molecule-1 levels (p < 0.05).
Conclusion: These results suggest that plasma TM levels may reflect a sever
ity of AD and/or endothelial cell activation induced by an allergic inflamm