Role of TGF-beta in immune-evasion of cancer

Citation
C. Beck et al., Role of TGF-beta in immune-evasion of cancer, MICROSC RES, 52(4), 2001, pp. 387-395
Citations number
132
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Multidisciplinary
Journal title
MICROSCOPY RESEARCH AND TECHNIQUE
ISSN journal
1059-910X → ACNP
Volume
52
Issue
4
Year of publication
2001
Pages
387 - 395
Database
ISI
SICI code
1059-910X(20010215)52:4<387:ROTIIO>2.0.ZU;2-O
Abstract
One of the major obstacles in tumor-immunology is the outgrowth of malignan t tumors despite their immunogenicity and recognition by the immune-system. Multiple mechanisms for this phenomenon have been proposed. We review the possible involvement of transforming growth factor beta (TGF-beta) in this context. TGF-beta is a cytokine with pleiotropic functions, involved in mul tiple physiologic processes including immunoregulation. Immune elimination of most cancers ultimately depends on cytolytic T cells (CTL). We propose a mechanism of specific suppression of cytolytic T cell (CTL)-responses medi ated through immunoglobulin-bound TGF-beta (IgG-TGF-beta), secreted by acti vated B cells, and a cell of myeloid origin. This mononuclear "Veto" cell p resumably binds IgG-TGF-beta through Fc-receptors and activates latent TGF- beta. The suggestion that B cell responses can inhibit tumor rejection is s upported by observations in B cell-deficient mice. Ways for enhancing effec tive cancer immunity by interfering with the network of interactions involv ing IgG-TGF-beta are discussed. Microsc. Res. Tech. 52:387-395, 2001. (C) 2 001 Wiley-Liss, Inc.