Polymeric thin films that resist the adsorption of proteins and the adhesion of bacteria

Citation
Rg. Chapman et al., Polymeric thin films that resist the adsorption of proteins and the adhesion of bacteria, LANGMUIR, 17(4), 2001, pp. 1225-1233
Citations number
56
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
LANGMUIR
ISSN journal
0743-7463 → ACNP
Volume
17
Issue
4
Year of publication
2001
Pages
1225 - 1233
Database
ISI
SICI code
0743-7463(20010220)17:4<1225:PTFTRT>2.0.ZU;2-L
Abstract
This paper describes the design and preparation of thin polymeric films tha t resist the adsorption of proteins and the adhesion of bacteria to an exte nt comparable to, or better than, self-assembled monolayers (SAMs) that pre sent tri(ethylene glycol) groups. These polymeric films were prepared by th e reaction of a polyamine, for example, poly(ethylenimine), with a SAM that presented interchain carboxylic anhydride groups, and by the subsequent co nversion of the amino groups of the polymer to amido groups on reaction wit h acyl chlorides. Polyamines functionalized with acetyl chloride produced f ilms that resisted the adsorption of protein and the adhesion of bacteria t o a useful extent. Functionalization of the polyamine with acyl chlorides t hat were derivatives of oligo(ethylene glycol) resulted in films that were 1-10 times more resistant than those obtained by acetylation. The removal o f hydrogen bond donor groups from the surface of the polyamines upon acylat ion seems to be important for the generation of films that resist the attac hment of proteins and bacteria.