Synthesis, characterization, and spectroscopic properties of three novel pentadentate copper(II) complexes related to the metal-chelating inhibitors against DNA binding with HIV-EP1

Citation
H. Kurosaki et al., Synthesis, characterization, and spectroscopic properties of three novel pentadentate copper(II) complexes related to the metal-chelating inhibitors against DNA binding with HIV-EP1, J CHEM S DA, (4), 2001, pp. 441-447
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
ISSN journal
1472-7773 → ACNP
Issue
4
Year of publication
2001
Pages
441 - 447
Database
ISI
SICI code
1472-7773(2001):4<441:SCASPO>2.0.ZU;2-2
Abstract
Three potentially five-coordinate peptide ligands having a pyridine and two histidine moieties, were synthesized to study their copper(II) complexatio n. Blue copper(II) complexes with deprotonated amide groups were isolated f rom methanolic solutions of the corresponding ligands with equimolar Cu(OAc )(2).H2O. The structures of two of them were determined by X-ray crystallog raphy. The Cu is coordinated to five nitrogen atoms in both complexes; the coordination geometry was a distorted square pyramid in one, and intermedia te between a square pyramid and trigonal bipyramid in the other. EPR spectr a in frozen methanol solutions at 77 K as well as visible absorption spectr a indicate that the distortion of the geometry around the copper is reduced by the introduction of an alkylamine substituent on the pyridine of the li gand and that the substituted complexes distort toward trigonal bipyramidal geometry compared to the unsubstituted one in solution.