Role of alginate O acetylation in resistance of mucoid Pseudomonas aeruginosa to opsonic phagocytosis

Citation
Gb. Pier et al., Role of alginate O acetylation in resistance of mucoid Pseudomonas aeruginosa to opsonic phagocytosis, INFEC IMMUN, 69(3), 2001, pp. 1895-1901
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
0019-9567 → ACNP
Volume
69
Issue
3
Year of publication
2001
Pages
1895 - 1901
Database
ISI
SICI code
0019-9567(200103)69:3<1895:ROAOAI>2.0.ZU;2-U
Abstract
Establishment and maintenance of chronic lung infections with mucoid Pseudo monas aeruginosa in patients with cystic fibrosis (CF) require that the bac teria avoid host defenses. Elaboration of the extracellular, O-acetylated m ucoid exopolysaccharide, or alginate, is a major microbial factor in resist ance to immune effecters. Here we show that O acetylation of alginate maxim izes the resistance of mucoid P. aeruginosa to antibody-independent opsonic killing and is the molecular basis for the resistance of mucoid P. aerugin osa to normally nonopsonic but alginate-specific antibodies found in normal human sera and sera of infected CF patients. O acetylation of alginate app ears to be critical for P. aeruginosa resistance to host immune effecters i n CF patients.