Atypical squamous metaplastic cells - Reproducibility, outcome, and diagnostic features on ThinPrep pap test

Citation
Mr. Quddus et al., Atypical squamous metaplastic cells - Reproducibility, outcome, and diagnostic features on ThinPrep pap test, CANC CYTOP, 93(1), 2001, pp. 16-22
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER CYTOPATHOLOGY
ISSN journal
0008-543X → ACNP
Volume
93
Issue
1
Year of publication
2001
Pages
16 - 22
Database
ISI
SICI code
0008-543X(20010225)93:1<16:ASMC-R>2.0.ZU;2-O
Abstract
BACKGROUND. Atypical squamous metaplastic (ASM) cells are associated with h igh-grade squamous intraepithelial lesions (HGSIL) in many cases. The repro ducibility of the diagnosis and biopsy follow-up results of cases designate d as ASM were studied at Women and Infants' Hospital of Rhode Island. METHODS, Of 180 patients with ASM who the authors examined from January 1, 1998 to September 30, 1998, 147 (81.7%) had subsequent biopsies. Results of the biopsies were tallied. Twenty cases were rescreened in a blinded fashi on to determine intra- and interobserver agreement and to identify diagnost ic features. RESULTS. Sixty-five (44.2%) cases of ASM had HGSIL on biopsy, 26 (17.7%) ha d low-grade squamous intraepithelial lesion, and 56 cases (38.1%) were beni gn. Overall individual consistency is 8 of 16 (50%), and overall agreement is 13 of 64 (20%). CONCLUSIONS. Sixty-two percent of cases designated as ASM cytologically wer e associated with SIL, primarily HGSIL, at biopsies. The findings underscor e the importance of this subcategory of atypical squamous cells. However, p oor reproducibility suggests the need for refined criteria and/or continuin g education, and obtaining second opinion. Cancer (Cancer Cytopathol) 2001; 93:16-22, (C) 2001 American Cancer Society.