Evidence for gliotoxin-glutathione conjugate adducts

Citation
Ph. Bernardo et al., Evidence for gliotoxin-glutathione conjugate adducts, BIOORG MED, 11(4), 2001, pp. 483-485
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
483 - 485
Database
ISI
SICI code
0960-894X(20010226)11:4<483:EFGCA>2.0.ZU;2-G
Abstract
The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200+/-100 M-1 at pH 7.0 at 25 degreesC. Under conditions where the reacti on was quenched rapidly with the addition of acid: gliotoxin-glutathione co njugate adducts were detected. (C) 2001 Elsevier Science Ltd. All rights re served.