Synthesis and biological activity of novel macrocyclic antifungals: Acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469

Citation
D. Barrett et al., Synthesis and biological activity of novel macrocyclic antifungals: Acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469, BIOORG MED, 11(4), 2001, pp. 479-482
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
479 - 482
Database
ISI
SICI code
0960-894X(20010226)11:4<479:SABAON>2.0.ZU;2-M
Abstract
A series of acylated analogues of the novel macrocyclic lipopeptidolactone FR901469 has been prepared and evaluated for antifungal and hemolytic activ ity. Several analogues displayed markedly reduced hemolytic potential and c omparable protective effects to the natural product in a mouse model of can didiasis. (C) 2001 Elsevier Science Ltd. All rights reserved.