D. Barrett et al., Synthesis and biological activity of novel macrocyclic antifungals: Acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469, BIOORG MED, 11(4), 2001, pp. 479-482
A series of acylated analogues of the novel macrocyclic lipopeptidolactone
FR901469 has been prepared and evaluated for antifungal and hemolytic activ
ity. Several analogues displayed markedly reduced hemolytic potential and c
omparable protective effects to the natural product in a mouse model of can
didiasis. (C) 2001 Elsevier Science Ltd. All rights reserved.