Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastoma

Citation
F. Sandra et al., Immunohistochemical evaluation of PCNA and Ki-67 in ameloblastoma, ORAL ONCOL, 37(2), 2001, pp. 193-198
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ORAL ONCOLOGY
ISSN journal
1368-8375 → ACNP
Volume
37
Issue
2
Year of publication
2001
Pages
193 - 198
Database
ISI
SICI code
1368-8375(200102)37:2<193:IEOPAK>2.0.ZU;2-W
Abstract
Thirty-two ameloblastoma tissues were immunohistochemically studied using m onoclonal anti-proliferating cell nuclear antigen (PCNA) and anti-Ki-67 ant ibodies. Positive cells were evaluated and analyzed in relation to the WHO classification, cytological pattern of the outer layer cell, clinical appea rance, tumor location, radiographic appearance and patient's age. In regard to the cytological pattern of the outer layer cells, the basal cell type h ad significantly higher PCNA and Ki-67 (P < 0.05) labeling indices than the cuboidal cell type. The solid type had significantly higher PCNA and Ki-67 (P < 0.05) labeling indices than the cystic and the mixed type. The labeli ng index of the younger patient was found to be the lowest, the middle age was in the middle and the older patient was the highest. These results indi cated that the proliferating activities of ameloblastomas are quite variabl e, and the evaluations of Ki-67 and PCNA seem to be good indicators to asse ss the proliferating activity of each type of ameloblastomas. (C) 2001 Else vier Science Ltd. All rights reserved.