Glycine reduces novelty- and methamphetamine-induced locomotor activity inneonatal ventral hippocampal damaged rats

Citation
K. Kato et al., Glycine reduces novelty- and methamphetamine-induced locomotor activity inneonatal ventral hippocampal damaged rats, NEUROPSYCH, 24(3), 2001, pp. 330-332
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPSYCHOPHARMACOLOGY
ISSN journal
0893-133X → ACNP
Volume
24
Issue
3
Year of publication
2001
Pages
330 - 332
Database
ISI
SICI code
0893-133X(200103)24:3<330:GRNAML>2.0.ZU;2-Y
Abstract
The use of neonatal ventral hippocampal nVH lesioned rats is well establish ed in animal models of schizophrenia. Moreover, the dysfunction of N-methyl -D-aspartate (NMDA) neurotransmission may play a crucial role in the pathop hysiology of schizophrenia. To examine the effect of glycine (GLY) in this animal model, we compared the effects of GLY (0.8 and 1.6 g/kg, IP) on loco motor activity induced by a novel environment (NOVEL) and methamphetamine ( MAP, 1.5 mg/kg, IF) in lesioned and sham-operated rats. Compared with sham rats, GLY significantly reduced NOVEL- and MAP-induced locomotor activity i n lesioned mts (p < .001 and p < .05, respectively). It is suggested that G LY attenuated nVH-induced hyperactivity, and that this effect was evident b oth in the presence and absence of MAP. The nVH lesions may result in a for m of hyperactivity that differs from normal locomotion in the degree to whi ch it is highly sensitive to regulation by GLY. (C) 2001 American College o f Neuropsychopharmacology. Published by Elsevier Science Inc.