HBV-specific peptide associated with heat-shock protein gp96

Citation
Sd. Meng et al., HBV-specific peptide associated with heat-shock protein gp96, LANCET, 357(9255), 2001, pp. 528-529
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
0140-6736 → ACNP
Volume
357
Issue
9255
Year of publication
2001
Pages
528 - 529
Database
ISI
SICI code
0140-6736(20010217)357:9255<528:HPAWHP>2.0.ZU;2-Y
Abstract
Glycoprotein 96 (gp96), a member of the heat-shock protein family, can elic it priming of antigen-specific cytotoxic T lymphocytes, when bound to antig enic viral or tumour peptides. We used direct peptide isolation from purifi ed gp96 and microsequencing to show that a virus-specific peptide Is bound to gp96 derived from liver tissues of patients with hepatitis B virus (HBV) -induced hepatocellular carcinoma. This virus-specific peptide has potentia l for engineering tumour vaccines against hepatocellular carcinoma and chro nic HBV infection.