Corticobasal degeneration presenting with nonfluent primary progressive aphasia: a clinicopathological study

Citation
M. Mimura et al., Corticobasal degeneration presenting with nonfluent primary progressive aphasia: a clinicopathological study, J NEUR SCI, 183(1), 2001, pp. 19-26
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN journal
0022-510X → ACNP
Volume
183
Issue
1
Year of publication
2001
Pages
19 - 26
Database
ISI
SICI code
0022-510X(20010115)183:1<19:CDPWNP>2.0.ZU;2-8
Abstract
A 62-year-old woman initially presented with slowly progressive nonfluent a phasia with minimal intellectual involvement. Echolalia and personality cha nge were prominent whereas parkinsonian features and signs suggesting parie tal lobe dysfunctions were not present. The patient's language deficit was consistent with transcortical motor aphasia. She did not manifest extrapyra midal signs. The patient was diagnosed as having Pick's disease or frontal lobe dementia. She died at age 65, 2 years and 9 months following disease o nset. Neuropathological findings including cytoskeletal abnormalities, howe ver, were clearly distinct from those of classical Pick's disease and were consistent with those reported in corticobasal degeneration (CBD). The dist ribution of her cortical lesions was accentuated in the frontal language-re lated area. The clinical manifestations in CBD are diverse, and primary pro gressive nonfluent aphasia should be considered as an initial symptom of CB D. Neuropathological examination of such patients should include cytoskelet al abnormality studies. (C) 2001 Elsevier Science B.V. All rights reserved.