Relationship of psychosis to aggression, apathy and function in dementia

Citation
Mj. Rapoport et al., Relationship of psychosis to aggression, apathy and function in dementia, INT J GER P, 16(2), 2001, pp. 123-130
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
ISSN journal
0885-6230 → ACNP
Volume
16
Issue
2
Year of publication
2001
Pages
123 - 130
Database
ISI
SICI code
0885-6230(200102)16:2<123:ROPTAA>2.0.ZU;2-2
Abstract
Background. Psychosis has been associated with aggression in dementia, but the nature of this relationship has been unclear. There has been very littl e research into the relations between apathy and functional status to psych osis in dementia. The purpose of this study is to investigate the relations hip between psychosis and aggression, apathy, and functional status in outp atients with dementia. Methods. The presence of psychosis was assessed by clinical interview and t wo scales: the Neuropsychiatric Inventory and the Columbia University Scale for Psychopathology in Alzheimer's Disease. The maximum likelihood estimat ion technique was used to determine the best estimate of the presence of ps ychosis. Aggression, apathy, and functional status (activities of daily liv ing: ADLs) were measured using structured instruments. Results. Sixty-one subjects were included. The CUSPAD and NPI provided low false positive and negative rates. ANCOVA analyses showed that psychosis wa s significantly associated with aggression, even when controlling for apath y, depression, and ADLs. Psychosis was related to apathy only when depressi on was controlled for. Hallucinations were related to impaired basic ADLs, even when depression and apathy were controlled for. Conclusions. Relationships were found between psychotic symptoms in dementi a and aggression as well as apathy and impaired functional status. These re lationships suggest pathophysiologic mechanisms and have possible treatment implications. Copyright (C) 2001 John Wiley & Sons, Ltd.