Are transoesophageal Doppler parameters a reliable guide to paediatric haemodynamic status and fluid management?

Sm. Tibby et al., Are transoesophageal Doppler parameters a reliable guide to paediatric haemodynamic status and fluid management?, INTEN CAR M, 27(1), 2001, pp. 201-205
Citations number
Categorie Soggetti
Aneshtesia & Intensive Care
Journal title
ISSN journal
0342-4642 → ACNP
Year of publication
201 - 205
SICI code
Objective: Transoesophageal Doppler (TOD) has been used in adults to optimi se left ventricular filling on the basis of the waveform parameters. We wis hed to see if a similar relationship exists in children, specifically: (a) whether change in thermodilution stroke volume (SV) following a fluid bolus corresponded to change in Doppler stroke distance, Doppler corrected flow time (FTc), or central venous pressure (CVP); (b) whether a response to flu id challenge (defined as an increase in SV of greater than 10%) can be pred icted on the basis of an absolute value for FTc or CVP prior to fluid bolus ; and (c) the relationship between FTc and systemic vascular resistance ind ex. Design: Prospective, comparison study. Setting: Sixteen-bed paediatric intensive care unit of a university hospita l. Patients: Ninety-four ventilated children were studied, median (range) age 25 months (4 days - 16 years). Diagnoses included: post-cardiac surgery (n = 58), sepsis/multi-organ failure (n = 29), respiratory disease (n = 5), an d other (n = 2). Interventions: A 4-MHz, 5.5-mm diameter, flexible TOD probe was placed when patients were haemodynamically stable. Five consecutive measurements of st roke distance and FTc were made and averaged, concurrently with five SV mea surements by femoral artery thermodilution. SV was then augmented by admini stration of fluid (10 ml/kg), and haemodynamic recordings were repeated. Measurements and main results: The median (range) SV was 17 ml (2-64 ml). T he median coefficients of variation were 3.9% for SV, 3.5% for stroke dista nce, and 3.1% for FTc. Changes in SV were accurately tracked by changes in stroke distance (mean bias 1.8%, limits of agreement +/- 17%), but not by F Tc or CVP. FTc was weakly inversely correlated with systemic vascular resis tance (r = -0.15, P < 0.05). Among non-cardiac patients (n=36), the optimal FTc that predicted an improvement in SV following fluid bolus was 0.394 s (area under ROC curve 0.756), giving a sensitivity of 90%, specificity of 6 2%, positive predictive value of 47%, and a negative predictive value of 94 %. CVP was a poor predictor for all patient groups. Conclusions: TOD stroke distance is able to follow changes in SV following fluid bolus amongst ventilated children, and can predict when further volum e loading is unlikely to improve SV amongst general, but not cardiac ICU pa tients. CVP is a poor discriminator of volume status in this group of patie nts.