The founder mutations in the BRCA1, BRCA2, and ATM genes in Moroccan Jewish women with breast cancer

Citation
Y. Kreiss et al., The founder mutations in the BRCA1, BRCA2, and ATM genes in Moroccan Jewish women with breast cancer, GENET TEST, 4(4), 2000, pp. 403-407
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC TESTING
ISSN journal
1090-6576 → ACNP
Volume
4
Issue
4
Year of publication
2000
Pages
403 - 407
Database
ISI
SICI code
1090-6576(200024)4:4<403:TFMITB>2.0.ZU;2-7
Abstract
To gain insight into the molecular mechanisms underlying the inherited pred isposition to breast cancer in non-Ashkenazi Jews, we genotyped 54 Jewish M oroccan women with breast cancer, unselected for family history of cancer, for the predominant Jewish mutations in BRCA1, BRCA2, and ATM, One patient (2%) was found to have the 185delAG BRCA1 mutation, none was a carrier of t he 6174delT BRCA2 mutation, and 2/54 (4%) were heterozygous for the ATM mut ation. These rates were not significantly different from the rates in the g eneral non-Ashkenazi population. These preliminary data may indicate that t he predominant Jewish mutations in BRCA1, BRCA2, and ATM genes contribute l ittle, if any, to breast cancer predisposition and risk among Moroccan Jews .