Antiprothrombin autoantibodies in severe preeclampsia and abortion

Citation
T. Akimoto et al., Antiprothrombin autoantibodies in severe preeclampsia and abortion, AM J MED, 110(3), 2001, pp. 188-191
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
AMERICAN JOURNAL OF MEDICINE
ISSN journal
0002-9343 → ACNP
Volume
110
Issue
3
Year of publication
2001
Pages
188 - 191
Database
ISI
SICI code
0002-9343(20010215)110:3<188:AAISPA>2.0.ZU;2-2
Abstract
PURPOSE: We examined the levels of autoantibodies against prethrombin-1 and fragment-1 in pregnant women to determine the type of autoantibodies that were associated with severe, preeclampsia or spontaneous abortion. SUBJECTS AND METHODS: We measured autoantibodies bound to prethrombin-1, pr ethromhin-1, and fragment-1 by using an enzyme-linked immunosorbent assay ( ELISA) in 12 healthy nonpregnant women, 36 women with normal pregnancies, 2 8 pregnant women with severe preeclampsia, and 19 pregnant women who subseq uently had spontaneous abortion. RESULTS: Plasma samples in 10 (36%) of the 28 women with severe preeclampsi a and 11 (58%) of the 19 women with spontaneous abortion were positive for antiprothrombin antibodies as compared with 3 (9%) of the 36 women with nor mal pregnancies. AU II of the positive samples from women who had spontaneo us abortions were positive for antiprethrombin-1 antibody, but only 1 was p ositive for antifragment-1 antibody. The mean ( +/- SD) titer of antiprethr ombin-1 1 antibodies in patients with spontaneous abortion (36 +/- 9 U) was higher than that in women with normal pregnancies (10 +/- 4 U; P < 0.01). Antiprethrombin-1 antibody was detected in only 28 women with severe preecl ampsia, whereas all 10 women with antiprethrombin antibodies were positive for antifragment-1 antibody. The antifragment-1 antibody titer in patients with severe pre eclampsia (49 +/- 15 U) was higher than in women with norma l pregnancies(l3 +/- 6 U, P <0.01). CONCLUSIONS: There is a strong and specific association between various typ es of antiprothrombin antibodies with severe preeclampsia and spontaneous a bortion. (C)2001 by Excerpta Medica, Inc.