First total synthesis of mosin B

Citation
N. Maezaki et al., First total synthesis of mosin B, ORG LETT, 3(3), 2001, pp. 429-432
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
3
Issue
3
Year of publication
2001
Pages
429 - 432
Database
ISI
SICI code
1523-7060(20010208)3:3<429:FTSOMB>2.0.ZU;2-Y
Abstract
[GRAPHICS] The first total synthesis of mosin B and a diastereomer was accomplished us ing asymmetric desymmetrization of the sigma -symmetric diol and the Nozaki -Hiyama-Kishi reaction as the key steps. The THF core segment was stereosel ectively constructed employing a stereodivergent synthesis starting from a common intermediate, 4-cyclohexene-1,2-diol, based on a desymmetrization st rategy. By virtue of these synthetic results, it is suggested that the abso lute configuration is 1a.