The first total synthesis of mosin B and a diastereomer was accomplished us
ing asymmetric desymmetrization of the sigma -symmetric diol and the Nozaki
-Hiyama-Kishi reaction as the key steps. The THF core segment was stereosel
ectively constructed employing a stereodivergent synthesis starting from a
common intermediate, 4-cyclohexene-1,2-diol, based on a desymmetrization st
rategy. By virtue of these synthetic results, it is suggested that the abso
lute configuration is 1a.