Identification of XAF1 as an antagonist of XIAP anti-caspase activity

Citation
P. Liston et al., Identification of XAF1 as an antagonist of XIAP anti-caspase activity, NAT CELL BI, 3(2), 2001, pp. 128-133
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
1465-7392 → ACNP
Volume
3
Issue
2
Year of publication
2001
Pages
128 - 133
Database
ISI
SICI code
1465-7392(200102)3:2<128:IOXAAA>2.0.ZU;2-6
Abstract
The inhibitors of apoptosis (IAPs) suppress apoptosis through the inhibitio n of the caspase cascade and thus are key proteins in the control of cell d eath. Here we have isolated the protein XIAP-associated factor 1 (XAF1) on the basis of its ability to bind XIAP, a member of the IAP family. XIAP sup presses caspase activation and cell death in vitro, and XAF1 antagonizes th ese XIAP activities. Expression of XAF1 triggers a redistribution of XIAP f rom the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal ti ssues, but is present at low or undetectable levels in many different cance r cell lines. Loss of control over apoptotic signalling is now recognized a s a critical event in the development of cancer. Our results indicate that XAF1 may be important in mediating the apoptosis resistance of cancer cells .