Effect of furosemide on renal excretion of oxypurinol and purine bases

Citation
T. Yamamoto et al., Effect of furosemide on renal excretion of oxypurinol and purine bases, METABOLISM, 50(2), 2001, pp. 241-245
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN journal
0026-0495 → ACNP
Volume
50
Issue
2
Year of publication
2001
Pages
241 - 245
Database
ISI
SICI code
0026-0495(200102)50:2<241:EOFORE>2.0.ZU;2-K
Abstract
To examine whether furosemide affects the plasma concentration and urinary excretion of purine bases and oxypurinol, we administered allopurinol (300 mg) orally to 6 healthy subjects and then administered furosemide (20 mg) i ntravenously 10 hours later. Furosemide (20 mg) decreased the urinary excre tion of uric acid by 40% (P < .01), oxypurinol by 39% (P < .05), and xanthi ne by 43% (P < .05) and the fractional clearance of uric acid by 45% (P < . 01) and oxypurinol by 34% (P < .05) when measured 1 to 2 hours after admini stration. Moreover, furosemide increased the plasma concentration of uric a cid by 6% at 1.5 hours after administration. These results indicate that fu rosemide may decrease the urinary excretion of uric acid and oxypurinol by acting on their common renal transport pathway(s), In addition, it is sugge sted that the effect of furosemide on oxypurinol is clinically important, s ince the hypouricemic effect of allopurinol may become more potent as a res ult. Copyright (C) 2001 by W.B. Saunders Company.