Recognition and selective transport of nucleic acid components through molecularly imprinted polymeric membranes

Citation
M. Yoshikawa et al., Recognition and selective transport of nucleic acid components through molecularly imprinted polymeric membranes, MACRO MAT E, 286(1), 2001, pp. 52-59
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULAR MATERIALS AND ENGINEERING
ISSN journal
1438-7492 → ACNP
Volume
286
Issue
1
Year of publication
2001
Pages
52 - 59
Database
ISI
SICI code
1438-7492(200101)286:1<52:RASTON>2.0.ZU;2-C
Abstract
Full Paper: To induce "molecular memory" in a membrane substrate at the sam e time that the membrane was prepared from its polymer solution, an alterna tive molecular imprinting technique was applied. Upon membrane formation, a "molecular memory" of the imprint molecule is retained by the formed membr ane that recognizes or favors interaction with print molecule analogues. In the present study, polystyrene resin bearing a tetrapeptide derivative, a derivative of natural polymer, and an entirely non-chiral synthetic polymer were adopted as candidate materials to form molecular recognition sites. 9 -Ethyladenine was adopted as a print molecule. These molecularly imprinted polymeric membranes recognized and adsorbed adenosine (As), which is an ana logue of the print molecule, in preference to guanosine (Gs) from As/Gs mix tures. However Gs was permeated in preference to As contrary to adsorption selectivity, possibly because of the relatively high affinity between As an d the membrane.