Vitamin E inhibition of platelet aggregation is independent of antioxidantactivity

Citation
Je. Freedman et Jf. Keaney, Vitamin E inhibition of platelet aggregation is independent of antioxidantactivity, J NUTR, 131(2), 2001, pp. 374S-377S
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Food Science/Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF NUTRITION
ISSN journal
0022-3166 → ACNP
Volume
131
Issue
2
Year of publication
2001
Pages
374S - 377S
Database
ISI
SICI code
0022-3166(200102)131:2<374S:VEIOPA>2.0.ZU;2-F
Abstract
Vitamin E is the principal lipid-soluble antioxidant in human plasma, and s ome studies indicate that it may provide cardiovascular protection. To inve stigate putative mechanisms for vitamin E in this regard, the effect of vit amin E on vascular function and platelet aggregation was examined. In anima l models of endothelial dysfunction, vitamin E improved the activity of end othelium-derived nitric oxide, and this effect was not dependent upon the a ntioxidant protection of LDL. In fact, vitamin E improved endothelial funct ion in part due to the inhibition of protein kinase C (PKC) stimulation. Th is activity of vitamin E was examined in platelets, and vitamin E inhibited platelet aggregation in part through a mechanism that involves PKC, Moreov er, the platelet inhibitory activity of vitamin E was independent of its an tioxidant action because platelet inhibition was still observed with isofor ms of vitamin E that were devoid of antioxidant activity.