Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis

Citation
M. Sanguinetti et al., Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis, J CLIN MICR, 39(2), 2001, pp. 816-819
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
0095-1137 → ACNP
Volume
39
Issue
2
Year of publication
2001
Pages
816 - 819
Database
ISI
SICI code
0095-1137(200102)39:2<816:FPIDTM>2.0.ZU;2-R
Abstract
We report a case of fatal pulmonary infection caused by Mycobacterium absce ssus in a young patient with cystic fibrosis, who underwent bipulmonary tra nsplantation after a 1-year history of severe lung disease. Fifteen days af ter surgery he developed septic fever with progressive deterioration in lun g function. M. abscessus, initially isolated from a pleural fluid specimen, was then recovered from repeated blood samples, suggesting a disseminated nature of the mycobacterial disease. Drug susceptibility testing assay, per formed on two sequential isolates of the microorganism, showed a pattern of multidrug resistance. Despite aggressive therapy with several antimycobact erial drugs, including clarithromycin, the infection persisted, and the pat ient died.