Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast

Citation
N. Ariga et al., Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast, INT J CANC, 95(1), 2001, pp. 67-72
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF CANCER
ISSN journal
0020-7136 → ACNP
Volume
95
Issue
1
Year of publication
2001
Pages
67 - 72
Database
ISI
SICI code
0020-7136(20010120)95:1<67:SEOFAP>2.0.ZU;2-W
Abstract
Fibroblast activation protein (FAP)/seprase is a serine integral membrane p roteinase with gelatinase activity, which is expressed by activated fibrobl asts in the stroma of various epithelial cancers, mesenchymal tumors and br east-cancer cells, as well as during wound repair. However, the pathophysio logic significance of its expression remains poorly understood. The present study was designed to reveal the impact of stromal expression of FAP/sepra se on survival in human breast cancer. Immunohistochemical expression of FA P/seprase was restricted to stromal fibroblasts adjacent to tumor-cell nest s but not cancer cells, which was confirmed by double-labeling immunohistoc hemistry. Clinicopathologic analysis revealed that more abundant FAP/sepras e expression in 112 cases of invasive ductal carcinoma is associated with l onger overall and disease-free survival. Multivariate analysis with other c linicopathologic factors demonstrated that FAP/seprase expression is an ind ependent prognostic factor. The effect on the survival rate of FAP/seprase was also apparent in cases with lymph node metastasis. FAP/seprase expressi on is one of the manifestations of the stromal reaction (Le., matrix turnov er); thus, invasive ductal carcinomas with fewer stromal reactions expressi ng FAP/seprase may be more aggressive. (C) 2001 Wiley-Liss, Inc.