Connatal tuberculosis in an extremely low birth weight infant: case reportand management of exposure to tuberculosis in a neonatal intensive care unit

Citation
M. Saitoh et al., Connatal tuberculosis in an extremely low birth weight infant: case reportand management of exposure to tuberculosis in a neonatal intensive care unit, EUR J PED, 160(2), 2001, pp. 88-90
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN journal
0340-6199 → ACNP
Volume
160
Issue
2
Year of publication
2001
Pages
88 - 90
Database
ISI
SICI code
0340-6199(200102)160:2<88:CTIAEL>2.0.ZU;2-7
Abstract
A case of connatal tuberculosis in an extremely low birth weight infant is reported. The patient was a female with a birth weight of 973 g born in the 27th week of pregnancy. She developed respiratory distress and signs of in fection immediately after birth, which did not respond to mechanical ventil ation, antibiotics, and corticosteroid therapy. Connatal tuberculosis was c onfirmed at 48 days of age by isolation of Mycobacterium tuberculosis from the infant's tracheal aspirate and the mother's menstrual discharge. The in fant died of respiratory failure at 90 days of age. Mantoux tuberculin skin tests (TST) were performed on 99 infants, 144 medical staff members, and t wo family members. TST conversion occurred in three medical staff members, and preventive therapy with isoniazid was initiated. Eight exposed infants had normal chest X-rays and negative gastric aspirates for acid-fast bacill i and all received preventive isoniazid therapy. No case of tuberculosis de veloped during the 2-year follow-up period. Conclusion Connatal tuberculosis should be considered in neonatal respirato ry infection resistant to antibiotics. Prevention of transmission of tuberc ulosis on the neonatal intensive care unit by chemoprophylaxis is important .