Malignant eccrine spiradenoma: A case report and review od the literature

Citation
M. Ishikawa et al., Malignant eccrine spiradenoma: A case report and review od the literature, DERM SURG, 27(1), 2001, pp. 67-70
Citations number
27
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Dermatology
Journal title
DERMATOLOGIC SURGERY
ISSN journal
1076-0512 → ACNP
Volume
27
Issue
1
Year of publication
2001
Pages
67 - 70
Database
ISI
SICI code
1076-0512(200101)27:1<67:MESACR>2.0.ZU;2-X
Abstract
BACKGROUND. Eccrine spiradenoma is a well-differentiated benign tumor of th e sweat glands. Malignant change arising within eccrine spiradenoma is rare . OBJECTIVE. We describe a patient with malignant eccrine spiradenoma exhibit ing both carcinomatous and sarcomatous differentiation, METHODS. Case report and literature review. RESULTS. A 37-year-old woman noted enlargement of a left axillary tumor tha t had been present for 20 years. The tumor was resected and the specimen, m easuring 3.0 cm x 1.5 cm, revealed an encapsulated benign eccrine spiradeno ma as well as an undifferentiated carcinoma possessing both carcinomatous a nd sarcomatous components, A transition zone was evident between the benign eccrine spiradenoma and the undifferentiated carcinoma, suggesting that th e latter had arisen from the benign tumor, The malignant areas consisted pr incipally of undifferentiated carcinoma (70%), although squamous cell carci noma (10%), adenocarcinoma (10%), and chondrosarcomatous (10%) components w ere also present. Numerous mitotic figures were noted within the areas of m alignant change, suggesting that the tumor was aggressive in nature, The pa tient died of systemic metastases 7 months after diagnosis. CONCLUSION. Although eccrine spiradenomas are usually benign, they can, on rare occasions, undergo malignant transformation. This case report describe s one such occurrence of malignant transformation of a benign eccrine spira denoma that unfortunately resulted in the patient's death from systemic met astases 7 months after diagnosis.