Interleukin 20: Discovery, receptor identification, and role in epidermal function

Citation
H. Blumberg et al., Interleukin 20: Discovery, receptor identification, and role in epidermal function, CELL, 104(1), 2001, pp. 9-19
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
0092-8674 → ACNP
Volume
104
Issue
1
Year of publication
2001
Pages
9 - 19
Database
ISI
SICI code
0092-8674(20010112)104:1<9:I2DRIA>2.0.ZU;2-L
Abstract
A structural, profile-based algorithm was used to identify interleukin 20 ( IL-20), a novel IL-10 homolog. Chromosomal localization of IL-20 led to the discovery of an IL-10 family cytokine cluster. Overexpression of IL-20 in transgenic (TG) mice causes neonatal lethality with skin abnormalities incl uding aberrant epidermal differentiation. Recombinant IL-20 protein stimula tes a signal transduction pathway through STAT3 in a keratinocyte cell line , demonstrating a direct action of this ligand. An IL-20 receptor was ident ified as a heterodimer of two orphan class II cytokine receptor subunits. B oth receptor subunits are expressed in skin and are dramatically upregulate d in psoriatic skin. Taken together, these results demonstrate a role in ep idermal function and psoriasis for IL-20, a novel cytokine identified solel y by bioinformatics analysis.