The effect of age on the response of the rat brains to continuous beta-amyloid infusion

Authors
Citation
S. Nag et F. Tang, The effect of age on the response of the rat brains to continuous beta-amyloid infusion, BRAIN RES, 889(1-2), 2001, pp. 303-307
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
889
Issue
1-2
Year of publication
2001
Pages
303 - 307
Database
ISI
SICI code
0006-8993(20010119)889:1-2<303:TEOAOT>2.0.ZU;2-1
Abstract
Young (3 months old) and aging (18-21 months old) rats were Infused intrace rebroventricularly with beta -amyloid (1-40; 4.2 nmol) for 14 days. In both age groups, beta -amyloid led to deficits in water-maze and decreased chol ine acetyltransferase activity and somatostatin levels. Cortical substance P levels also decreased whereas neuropeptide Y levels remained unaltered. T here were no significant age dependent differences among these neurochemica ls except a decrease in hippocampal neuropeptide Y levels in the aging grou p. It is concluded that young and aging rat brains respond similarly to bet a -amyloid infusion. (C) 2001 Elsevier Science B.V. All rights reserved.