We report the discovery of securiosides A (1) and B (2). novel acylated tri
terpene bisdesmosides, isolated from tie roots of Securidaca inappendiculat
a. Securiosides A and B showed potent selective cytotoxic activity against
M-CSF-stimulated macrophages and were suggested to have potential as new ag
ents for the treatment of inflammatory diseases such as RA and atherosclero
sis. (C) 2001 Elsevier Science Ltd. All rights reserved.