Synthesis and photodynamic activity of a cationic zinc monoazaporphyrin bearing a nitrogen atom at the peripheral position

Citation
S. Kai et al., Synthesis and photodynamic activity of a cationic zinc monoazaporphyrin bearing a nitrogen atom at the peripheral position, BIOORG MED, 11(3), 2001, pp. 363-365
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
363 - 365
Database
ISI
SICI code
0960-894X(20010212)11:3<363:SAPAOA>2.0.ZU;2-Y
Abstract
A new cationic monoazaporphyrin, zinc 2-aza-8 12,13,17-tetraethyl-2,3,7,18- tetramethylporphyrinium iodide 3 was synthesized. Photodynamic activity of 3 in degradation of 2',3'-isopropylideneguanosine 4 was compared with 2-aza -8,12,13,17-tetraethyl-3,7,18-trimethylporphyrin 1, zinc 2-aza-8,12,13,17-t etraethyl-3,7,18-trimethylporphyrin 2, and hematoporphyrin 5. The quarterna ry ammonium 3 showed a remarkable increase of photodynamic activity compare d with 5, although no appreciable difference in the activity was observed b etween 1 and 5. (C) 2001 Elsevier Science Ltd. All rights reserved.