The identification of alpha-ketoamides as potent inhibitors of hepatitis Cvirus NS3-4A proteinase

Citation
Jm. Bennett et al., The identification of alpha-ketoamides as potent inhibitors of hepatitis Cvirus NS3-4A proteinase, BIOORG MED, 11(3), 2001, pp. 355-357
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
3
Year of publication
2001
Pages
355 - 357
Database
ISI
SICI code
0960-894X(20010212)11:3<355:TIOAAP>2.0.ZU;2-H
Abstract
Peptides based upon the non-prime side residues of the NS4A-4B cleavage sit e of hepatitis C virus (HCV) NS3-4A proteinase containing an alpha -ketoami de moiety in place of the scissile amide bond are potent inhibitors of this enzyme. (C) 2001 Elsevier Science Ltd. All rights reserved.