Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma

Citation
S. Aoki et al., Protective effect of fluvastatin on degradation of apolipoprotein B by a radical reaction in human plasma, BIOL PHAR B, 24(2), 2001, pp. 123-126
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
2
Year of publication
2001
Pages
123 - 126
Database
ISI
SICI code
0918-6158(200102)24:2<123:PEOFOD>2.0.ZU;2-Z
Abstract
Fluvastatin, which is a synthetic 3-hydroxy-3-methylglutaryl coenzyme (HMG- CoA) reductase inhibitor, its metabolites (M2, M3 and M4) and trolox all in hibited the decrease of apolipoprotein B-100 (apoB) and alpha -tocopherol i n a radical reaction of human plasma initiated by Cu2+. The concentrations of fluvastatin, M2, M3, M4 and trolox for 50% inhibition (IC50) of apoB fra gmentation were 405, 8.55, 1.75, 305, and 43.4 muM, respectively. The IC50 value of pravastatin, which is another HMG-CoA reductase inhibitor, was 288 0 muM, showing that pravastatin is not an effective antioxidant. Although f luvastatin, its metabolites and trolox inhibited the decrease of alpha -toc opherol in a similar manner to that of apoB, pravastatin did not significan tly inhibit the decrease of a; tocopherol. Since oxidation of low density l ipoprotein (LDL) is an important step in the initiation and progression of atherosclerosis, fluvastatin may reduce the risk of atherosclerosis not onl y by lowering plasma cholesterol but also by protecting LDL from oxidation.