Broadband proton decoupling for in vivo brain spectroscopy in humans

Citation
Pb. Barker et al., Broadband proton decoupling for in vivo brain spectroscopy in humans, MAGN RES M, 45(2), 2001, pp. 226-232
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
MAGNETIC RESONANCE IN MEDICINE
ISSN journal
0740-3194 → ACNP
Volume
45
Issue
2
Year of publication
2001
Pages
226 - 232
Database
ISI
SICI code
0740-3194(200102)45:2<226:BPDFIV>2.0.ZU;2-X
Abstract
A new decoupling sequence, PEAR, is described for broadband heteronuclear d ecoupling in vivo in humans at 1.5T. The sequence uses non-adiabatic, frequ ency- and amplitude-modulated inversion pulses designed to minimize decoupl ing sidebands at low applied gammaB(2) RF field levels and to cover only th e narrow range of resonance offsets encountered in practice. The offset dep endence of the decoupling efficiency of PEAR is demonstrated and compared t o the conventional WALTZ-4 sequence. At the same average power levels, PEAR had slightly reduced bandwidth but significantly less intense decoupling s idebands. Applications of PEAR are shown in vivo in the human brain both fo r P-31 and natural abundance C-13 spectroscopy using volume decoupling coil s. The PEAR sequence allows whole brain {H-1}-C-13 decoupling to be perform ed at 1.5T with a standard head coil within FDA guidelines for RF power dep osition. Magn Reson Med 45:226-232, 2001. (C) 2001 Wiley-Liss, Inc.