Synthesis of sugar-modified derivatives of the unusual nucleoside oxanosine and its carbocyclic analogs as potential inhibitors of HIV

Citation
Y. Saito et al., Synthesis of sugar-modified derivatives of the unusual nucleoside oxanosine and its carbocyclic analogs as potential inhibitors of HIV, J CHEM S P1, (3), 2001, pp. 298-304
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
1472-7781 → ACNP
Issue
3
Year of publication
2001
Pages
298 - 304
Database
ISI
SICI code
1472-7781(2001):3<298:SOSDOT>2.0.ZU;2-X
Abstract
A series of sugar-modified derivatives of oxanosine and its carbocyclic ana logs were synthesized from natural oxanosine and (-)-2-azabicyclo[2.2.1]hep t-5-en-3-one, respectively. Among nucleosides tested for anti-HIV activitie s in vitro, oxanosine 1, its 5'-monophosphate 9, and 2'-deoxyoxanosine 8 re duced the number of HIV particles in CEM cells to almost the same level as ddI.