Phytochemical analysis of the leaves of Cestrum nocturnum (Solanaceae) resu
lted in the isolation of two new flavonol glycosides (1, 2) and seven stero
idal saponins (3-9), including four new ones (4, 6, 7, and 9). The structur
es of the new compounds were determined by spectroscopic analysis, includin
g 2D NMR data, and the results of hydrolytic cleavage. Cytotoxic activities
of the isolated compounds against human oral squamous cell carcinoma-(HSC-
2) cells and normal human gingival fibroblasts are reported.