Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy

Citation
Y. Tomino et al., Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy, J CL LAB AN, 15(1), 2001, pp. 25-29
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF CLINICAL LABORATORY ANALYSIS
ISSN journal
0887-8013 → ACNP
Volume
15
Issue
1
Year of publication
2001
Pages
25 - 29
Database
ISI
SICI code
0887-8013(2001)15:1<25:SCCMPT>2.0.ZU;2-B
Abstract
The relationship between the levels of serum cystatin C and the prognostic stages of IgA nephropathy was determined in a multicenter trial in Japan. T he levels of serum cystatin C in patients with IgA nephropathy were measure d using the Dade Behring N Latex Cystain C assay. In 1995, the Joint Commit tee of the Special Study Group on Progressive Glomerular Diseases, Ministry of Health and Welfare of Japan, and the Japanese Society of Nephropathy re ported four prognostic stages. These are: good prognosis group (Group I), r elatively good prognosis group (Group II), relatively poor prognosis group (Group III), and poor prognosis group (Group IV), for this disease. Three-h undred and six patients with IgA nephropathy and other glomerular diseases were examined. There were no significant changes in the levels of serum cre atinine (Cr) or creatinine clearance (CCr) between Group I and Group II. Th e mean levels of serum cystatin C in Group II were significantly higher tha n those in Group I (P < 0.05). The mean levels of serum cystatin C in Group III or IV were significantly higher than those in Group I (P < 0.001, P < 0.005, respectively). These suggest that the measurement of serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy. J. Clin. Lab. Anal. 15:25-29, 2001. (C) 2001 Wiley-Liss, I nc.