In vitro synergy between cefepime and vancomycin against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis

Citation
A. Lozniewski et al., In vitro synergy between cefepime and vancomycin against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis, J ANTIMICRO, 47(1), 2001, pp. 83-86
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,Microbiology
Volume
47
Issue
1
Year of publication
2001
Pages
83 - 86
Database
ISI
SICI code
Abstract
The in vitro activity of cefepime combined with vancomycin was assessed by the chequerboard method against 35 clinical isolates of methicillin-suscept ible (MSSA, n = 8) or -resistant (MRSA, n = 10) Staphylococcus aureus and m ethicillin-susceptible (MSSE, n = 9) or -resistant (MRSE, n = 8) Staphyloco ccus epidermidis and S. aureus ATCC 25923 (MSSA). The combination was syner gic against 16 isolates and additive/indifferent against 20. For 10 of the clinical isolates (two MSSA, three MESA, two MSSE, three MRSE) and the refe rence strain, the interaction of cefepime and vancomycin was also determine d by the time-kill method. Except for one MESA isolate, synergic killing wa s demonstrated with clinically achievable concentrations of vancomycin (0.5 -1 mg/L) and cefepime (methicillin-susceptible isolates: 0.5-1 mg/L; methic illin-resistant isolates: 2-64 mg/L).