Influence of TT virus on the clinical course of alcoholic liver disease

Citation
H. Tokita et al., Influence of TT virus on the clinical course of alcoholic liver disease, HEPATOL RES, 19(2), 2001, pp. 180-193
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
HEPATOLOGY RESEARCH
ISSN journal
1386-6346 → ACNP
Volume
19
Issue
2
Year of publication
2001
Pages
180 - 193
Database
ISI
SICI code
1386-6346(200102)19:2<180:IOTVOT>2.0.ZU;2-O
Abstract
The sera of 43 patients with alcoholic liver disease (ALD) who abstained fr om. alcohol for 4 weeks, were tested for TT virus (TTV) DNA by polymerase c hain reaction (PCR) using three different primer pairs (UTR PCR, N22 PCR an d genotype-1 PCR). The clinical course of the TTV DNA-positive and -negativ e groups was compared. By UTR PCR which detects all TTV genotypes, TTV DNA was detected in 40 patients (93%). N22 PCR which detects primarily TTV geno types 1-6, detected TTV DNA in 17 patients (40%). The alanine aminotransfer ase (ALT) level 4 weeks after the start of abstinence was significantly hig her and the rate of change in ALT {[(ALT on admission - ALT 4 weeks after a bstinence)/(ALT on admission)] x 100} was lower in the patients who were po sitive by N22 PCR, than in those who were negative by N22 PCR. Twelve patie nts (28%) were positive for TTV genotype 1. In the TTV genotype 1-positive group, the ALT 4 weeks after the start of abstinence was significantly high er, and the improvement rates of ALT, gamma -glutamyl transpeptidase and al kaline phosphatase levels were lower than those in the TTV genotype 1-negat ive group. These results suggest that certain genotypes of TTV may interfer e with the improvement of liver function following the start of abstinence in ALD patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved .