A comparative study of corneal endothelial changes induced by different durations of soft contact lens wear

Citation
Js. Lee et al., A comparative study of corneal endothelial changes induced by different durations of soft contact lens wear, GR ARCH CL, 239(1), 2001, pp. 1-4
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Optalmology
Journal title
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
ISSN journal
0721-832X → ACNP
Volume
239
Issue
1
Year of publication
2001
Pages
1 - 4
Database
ISI
SICI code
0721-832X(200101)239:1<1:ACSOCE>2.0.ZU;2-1
Abstract
Purpose: To analyze the effect on the morphologic characteristics of the co rneal endothelium of the duration of soft contact lens wearing periods. Met hods: Ninety soft contact lens wearers were divided into three groups: shor t-term users, for less than 5 years (n=60 eyes); intermediate-term users, f rom 6 years to 10 years (n=60); longterm users, for more than 10 years (n=6 0). Thirty non-contact lens wearers (60 eyes) were included as controls. Al l eyes were examined with a specular microscope. Analysis of covariance was used to detect any differences among the controls and the various soft con tact lens subgroups. Results: There was a significant correlation between d uration of soft contact lens use and morphologic changes of corneal endothe lium. All soft contact lens subgroups had a significantly greater coefficie nt of variation in cell size than non-contact lens users. The proportion of hexagonal cells and the mean corneal endothelial cell density in those usi ng soft contact lenses for more than 6 years were significantly lower than in the control group. Soft contact lens wear was significantly correlated w ith decreasing corneal endothelial cell densities with time. Conclusion: Th e coefficient of variation in cell size may be a sensitive indicator of ear ly morphologic changes of the corneal endothelium. As the decrease in cell density among the contact lens subgroups was significantly associated with the duration of soft contact lens wearing periods, it will be useful to inv estigate endothelial cell density for evaluation of corneal endothelial fun ction concerned with contact lens wearing.