Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3 ' A, CCR2-641, and CCR5-Delta 32) in global populations

Citation
B. Su et al., Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3 ' A, CCR2-641, and CCR5-Delta 32) in global populations, EUR J HUM G, 8(12), 2000, pp. 975-979
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EUROPEAN JOURNAL OF HUMAN GENETICS
ISSN journal
1018-4813 → ACNP
Volume
8
Issue
12
Year of publication
2000
Pages
975 - 979
Database
ISI
SICI code
1018-4813(200012)8:12<975:DOTHRP>2.0.ZU;2-4
Abstract
Chemokine receptors (CCR5, CXCR4 and CCR2) have been shown to be important co-receptors for HIV infection. Mutations at CCR5 (CCR5-Delta 32), CCR2 (CC R2-641), and stromal-derived factor SDF1 (SDF1-3'A), a primary ligand for C XCR4, are known to have protective effects against HIV-1 infection and the onset of AIDS symptoms. We studied the three-locus genotype frequency distr ibutions in 70 worldwide populations from a sample of 2341 individuals with out any known history of HIV-1 infection and AIDS symptoms. From these data , we estimated the risk of AIDS onset (relative hazard, RH) of each populat ion. This survey shows that the substantial allele frequency differences of each of these mutations translate into an extensive variation in relative hazards for AIDS in worldwide populations. However, no evidence of natural selection against the mutant gene carriers is detected. Finally, the combin ed three-locus genotype data predict the highest relative hazard (RH) in So uth-East Asia and Africa where AIDS is known to be more prevalent.