Germinated barley foodstuff feeding - A novel neutraceutical therapeutic strategy for ulcerative colitis

Citation
O. Kanauchi et al., Germinated barley foodstuff feeding - A novel neutraceutical therapeutic strategy for ulcerative colitis, DIGESTION, 63, 2001, pp. 60-67
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
DIGESTION
ISSN journal
0012-2823 → ACNP
Volume
63
Year of publication
2001
Supplement
1
Pages
60 - 67
Database
ISI
SICI code
0012-2823(2001)63:<60:GBFF-A>2.0.ZU;2-#
Abstract
A germinated barley foodstuff (GBF) contained glutamine-rich protein and th e hemicellulose-rich fiber was made from brewer's spent grain by physical i solation (milling and sieving). Both in vivo and in vitro studies demonstra ted that the fiber fraction of GBF supports maintenance of epithelial cell populations, facilitates epithelial repair, and suppresses epithelial nucle ar factor kappaB-DNA binding activity through generating increased short-ch ain fatty acid (especially butyrate) production by luminal microflora which includes Bifidobacterium and Eubacterium, thereby preventing experimental colonic injury. The fiber fraction also modulates stool water content by it s high water-holding capacity. The protein fraction which contains larger g lutamine prevents experimental small bowel injury. Based on these observati ons, clinical studies were initiated in patients with mild to moderate acti ve ulcerative colitis. The patients who had been unresponsive to or intoler ant of standard treatment received 30 grams of GBF feeding daily in a nonra ndomized, open-label fashion. At 4 weeks, this treatment resulted in a sign ificant clinical and endoscopic improve-ment independent of disease extent. The improvement was associated with an increase in stool butyrate concentr ations and in luminal Bifidobacterium and Eubacterium levels. After the end of GBF treatment the patients had an exacerbation of the disease. GBF was safe and well tolerated. These results indicate that GBF feeding is a poten tially attractive treatment in patients with ulcerative colitis. Copyright (C) 2001 S. Karger AG, Basel.