The immuno-inflammatory mechanism for tissue injury in inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis - Roles of the mucosal immune system

Citation
H. Nagura et al., The immuno-inflammatory mechanism for tissue injury in inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis - Roles of the mucosal immune system, DIGESTION, 63, 2001, pp. 12-21
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
DIGESTION
ISSN journal
0012-2823 → ACNP
Volume
63
Year of publication
2001
Supplement
1
Pages
12 - 21
Database
ISI
SICI code
0012-2823(2001)63:<12:TIMFTI>2.0.ZU;2-S
Abstract
The gastrointestinal mucosa is exposed to myriads of infectious and food an tigens, and a unique barrier mechanism handles them on the mucosal surface, and specific immune responses to these antigens call on the mucosal immune system in the mucosal tissues to maintain homeostasis of gastrointestinal functions and structure. Abrogation of these mucosal defense mechanisms may lead to alter immunologic homeostasis in the gastrointestinal tract and to induce pathological features of inflammatory bowel disease (IBD) and Helic obacter pylori-infected chronic active gastritis, including chronic active inflammation, mucosal atrophy and tissue injuries. Regardless of the initia ting cause of these long-standing chronic active mucosal inflammations, cha racteristic immuno-inflammatory mechanisms are involved in their pathogenes is, that is, similar and/or different specific prolonged impaired and exces sive immuno-inflammatory responses following the abrogation of the mucosal barrier system are present in the diseased mucosa with IBD and H. pylori in fection, respectively. Copyright (C) 2001 S. Karger AG, Basel.